Primary Aldosteronism—Changing Concepts in Diagnosis and Treatment (2003)

In patients with suspected primary aldosteronism, screening can be accomplished by measuring a morning (preferably 0800 h) ambulatory paired random PAC and PRA. This test may be performed while the patient is taking antihypertensive medications and without posture stimulation. Spironolactone is the only medication that will absolutely interfere with interpretation of the ratio.

Endocrinology -- Young 144 (6): 2208 Figure 1